Table I.
Functional enrichment analysis of gene clusters I–III.
| A, Cluster I | ||
|---|---|---|
| GO term | Adjusted P-value | Genes |
| Cell Cycle_Homo sapiens_R-HSA-1640170 | 9.9122×10−22 | TOP2A; AHCTF1; HSP90AB1; ZWILCH; MCM10; RSF1; SMC4; CDC20; NIPBL; CDC23; EXO1; NUF2; NEK2; KNTC1; YWHAG; RAB2A; HUS1; KIF23; TERF1; MASTL; SMC1A; CKAP5; YWHAZ; CDC25A; PSMA6; TFDP1; PSMA1; NUP50; PSME4; UBE2V2; DNA2; MAPRE1; PSMD12; SEH1L; PSMD11; PSMD14; PKMYT1; CENPA; SKA2; CCNB2; BRIP1; PSMB2; RBBP4; RAD21; E2F3; BUB3; CENPW; RRM2; UBE2C; GINS4; NUP153; TPX2; CENPF; PSMC1; PSMC2; CDK1; TUBGCP3; RAD1; LPIN2; NUP37 |
| Cell Cycle, Mitotic_Homo sapiens_R-HSA-69278 | 2.4984×10−19 | TOP2A; AHCTF1; HSP90AB1; ZWILCH; MCM10; SMC4; CDC20; NIPBL; CDC23; NUF2; NEK2; KNTC1; YWHAG; RAB2A; KIF23; MASTL; SMC1A; CKAP5; CDC25A; PSMA6; TFDP1; PSMA1; NUP50; PSME4; DNA2; MAPRE1; PSMD12; SEH1L; PSMD11; PSMD14; PKMYT1; CENPA; SKA2; CCNB2; PSMB2; RBBP4; RAD21; E2F3; BUB3; RRM2; UBE2C; GINS4; NUP153; TPX2; CENPF; PSMC1; PSMC2; CDK1; TUBGCP3; CENPO; LPIN2; NUP37 |
| M Phase_Homo sapiens_ R-HSA-68886 | 1.7904×10−16 | AHCTF1; PSMD12; PSMD11; SEH1L; PSMD14; ZWILCH; SMC4; CENPA; SKA2; CDC20; CCNB2; NIPBL; CDC23; PSMB2; RAD21; NUF2; KNTC1; BUB3; RAB2A; UBE2C; NUP153; KIF23; MASTL; SMC1A; CKAP5; PSMA6; CENPF; PSMA1; PSMC1; NUP50; PSMC2; PSME4; CDK1; CENPO; MAPRE1; LPIN2; NUP37 |
| Gene Expression_Homo sapiens_R-HSA-74160 | 1.7904×10−16 | ZNF496; TDRKH; GSK3B; SMG1; HNRNPU; ZC3H8; ADAR; EPRS; GLS; MED14; MED13; CASP10; EXO1; XPO5; RIOK1; YWHAG; ZIK1; SUPT16H; TBP; PDPK1; NCBP2; HUS1; BAZ1B; YWHAZ; SRRM1; SAP30; PSMA6; TFDP1; PSMA1; XRN1; TBL1XR1; NUP50; PSME4; TET3; RRAGD; POLR1E; DNA2; FYTTD1; ZNF274; PSMD12; SEH1L; PSMD11; RBM8A; PSMD14; RPN2; DDX21; TARS; BAZ2A; RNPC3; GTF2E1; BRIP1; MED30; PDCD11; PSMB2; RBBP4; PLAGL1; TRA2B; BMS1; ZKSCAN3; EIF4H; TP53BP2; IARS2; RPP14; EXOSC3; SKIL; EIF4B; POLR2K; DCAF13; ZNF420; WWTR1; WTAP; CBX3; UTP3; TAF11; CDC5L; NUP153; LSM4; GATAD2B; LSM3; TPX2; PHF5A; NR6A1; EIF5; POLR3B; PSMC1; PSMC2; CDK1; TAF4B; RAD1; CDK12; DCP1A; TAF2; RAN; FARSB; NUP37; EIF4G1 |
| Separation of Sister | 3.424×10−16 | PSMD12; AHCTF1; PSMD11; SEH1L; PSMD14; ZWILCH; CENPA; |
| Chromatids_Homo sapiens_R-HSA-2467813 | SKA2; CDC20; CDC23; PSMB2; RAD21; NUF2; KNTC1; BUB3; UBE2C; SMC1A; CKAP5; PSMA6; CENPF; PSMA1; PSMC1; PSMC2; PSME4; CENPO; MAPRE1; NUP37 | |
| B, Cluster II | ||
| GO term | Adjusted P-value | Genes |
| Cell Cycle_Homo sapiens_R-HSA-1640170 | 0.00026303 | DIDO1; ANKLE2; YWHAB; CDCA5; CDCA8; FOXM1; PSMA7; LMNA; E2F1; NUP88; PSMF1; PCNT; CSNK2A1; NCAPH2; TUBB; TOP3A; RANGAP1; LEMD2; POLA2; PSMC4; DKC1; MCM3; MCM4; KIF2C; SPC24; LPIN3 |
| Cell Cycle, Mitotic_Homo sapiens_R-HSA-69278 | 0.00061651 | ANKLE2; CSNK2A1; NCAPH2; CDCA5; TUBB; CDCA8; FOXM1; RANGAP1; LEMD2; PSMA7; POLA2; PSMC4; LMNA; MCM3; E2F1; MCM4; NUP88; KIF2C; PSMF1; PCNT; SPC24; LPIN3 |
| Axon guidance_Homo sapiens_R-HSA-422475 | 0.00231835 | BRAP; EPHB6; ROBO3; CSNK2A1; YWHAB; LIMK1; ARAF; FN1; PHB; PSMA7; DNM2; ARPC2; PSMC4; CFL1; GRB2; PSMF1; COL9A2; JAK3; EPHB1; SPTAN1; MYH10; CAMK2G |
| M Phase_Homo sapiens_R-HSA-68886 | 0.00231835 | ANKLE2; CSNK2A1; NCAPH2; CDCA5; CDCA8; RANGAP1; LEMD2; PSMA7; PSMC4; LMNA; NUP88; KIF2C; PSMF1; SPC24; LPIN3 |
| Immune System_Homo sapiens_R-HSA-168256 | 0.00274532 | DCTN5; CUL7; YWHAB; MAPKAP1; ARAF; ICAM5; PHB; UBE2Z; ECSIT; UBE2J2; ELK1; PLD3; PSMA7; ICAM1; ADCY5; RNF216; IRAK1; CFL1; KIF5A; ATP6V0A2; NUP88; PSMF1; JAK3; SPTAN1; CAMK2G; POLR2L; CTSA; BRAP; IL11RA; LIMK1; FN1; DNM2; MAVS; ARPC2; TRIM39; PSMC4; TRAF3; POLR3E; GRB2; UBA1; KIF2C; CRK; RAPGEF3; ATP6V1B1 |
| C, Cluster III | ||
| GO term | Adjusted P-value | Genes |
| Metabolism of proteins_Homo sapiens_R-HSA-392499 | 4.165×10−6 | TSTA3; COX19; ARF1; L3MBTL2; DCTN1; RPL31; POMT1; PARN; PIGV; ZDHHC2; RPS14; POFUT2; EXOSC4; RPL18A; FBXO4; RPL15; EXTL3; RPS10; MPDU1; PIAS4; SEC16B; NFYC; H3F3A; DYNC1LI2; RPS28; CCNE2; EEF1D; EIF3G; PDCL; EXOC3; RPL29; PFDN5 |
| Eukaryotic Translation Elongation_Homo sapiens_R-HSA-156842 | 0.00039761 | RPS14; RPS28; RPL18A; EEF1D; RPL31; RPL15RPL29; RPS10 |
| Selenocysteine synthesis_Homo sapiens_R-HSA-2408557 | 0.00039761 | RPS14; RPS28; RPL18A; RPL31; SECISBP2; RPL15; RPL29; RPS10 |
| Formation of a pool of free 40S subunits_Homo sapiens_R-HSA-72689 | 0.00052927 | RPS14; RPS28; RPL18A; RPL31; EIF3G; RPL15; RPL29; RPS10 |
| Infectious disease_Homo sapiens_R-HSA-5663205 | 0.0005955 | ARF1; RPL31; GTF2F1; RPS14; RPS28; CDK7; PSMB5; PSMC3; RPL18A; RPL15; RPL29; RPS10; VPS28; AP1M1 |
GO, Gene Ontology.