Table III.

Association analysis between mRNA expression of hub genes and clinicopathological parameters.

	Histology			Stage			MI			Grade
Gene	NEEC	EEC	P-value	III/IV	I/II	P-value	MI>50%	MI<50%	P-value	Grade 3	Grade 1/2	P-value
RRM2			0.2247			0.1653			0.2912			0.0003a
High	12	24		13	23		18	18		31	5
Low	104	336		110	330		177	263		243	197
CDC20			<0.0001a			0.1928			0.1579			<0.0001a
High	33	41		24	50		36	38		66	8
Low	83	319		99	303		159	243		208	194
TOP2A			0.0032b			0.0636			0.0996			0.0008a
High	13	13		11	15		15	11		23	3
Low	103	347		112	338		180	270		251	199
CDCA8			0.0001a			0.0426c			0.0099b			<0.0001a
High	32	41		26	47		40	33		66	7
Low	84	319		97	306		155	248		208	195
UBE2C			<0.0001a			0.0257c			0.0011b			<0.0001a
High	68	89		51	106		81	76		128	29
Low	48	271		72	247		114	205		146	173
TPX2			<0.0001a			0.0005a			0.0002a			<0.0001a
High	68	40		42	66		61	47		102	6
Low	48	320		81	287		134	234		172	196
CDK1			0.1159			0.0419c			0.0103c			0.0022b
High	17	99		19	31		29	21		39	11
Low	33	327		104	322		166	260		235	191
CCNB2			0.0281c			0.06326			0.0733			<0.0001a
High	26	49		26	49		38	37		63	12
Low	90	311		97	304		157	244		211	190
KIF2C			0.0079b			0.1460			0.0843			<0.0001a
High	22	34		19	37		29	27		53	3
Low	94	326		104	316		166	254		221	199
CENPF			0.0001a			0.0308c			0.0816			0.0004a
High	22	23		18	27		24	21		37	8
Low	94	337		105	326		171	260		237	194

EEC, endometrioid endometrial carcinoma; NEEC, non-endometrioid endometrial carcinoma; MI, myometrial invasion. Statistical analysis was conducted using Fisher's Exact test.

^aP<0.001

^bP<0.01

^cP<0.05.