Skip to main content
. Author manuscript; available in PMC: 2021 Aug 1.
Published in final edited form as: Int J Cardiol. 2020 Mar 12;312:1–9. doi: 10.1016/j.ijcard.2020.03.028

Figure 1.

Figure 1.

Effects of SK channels modulators on human coronary microvascular vasodilation. A, Dose-dependent vasodilation of human coronary microvessels in response to the endothelium-dependent, receptor independent vasodilator A23187 (10−9−10−5M), n =12/group, **p<0.001; B, Dose-dependent vasodilation of human coronary arterioles in response to the selective SK channel activator SKA-31 (10−9-10−5M) from patients with or without DM, n =12/group; *p<0.05. C, Coronary microvascular vasodilation in response to the selective SK channel activator SKA-31 (10−9-10−5M) in the presence or absence of endothelium denudation in the non-diabetic (ND) vessels, n= 5/group, *p<0.05 or **p<0.001 or ****p<0.0001 vs. Endothelium-intact; D, Coronary microvascular vasodilation in response to the selective SK channel activator SKA-31 (10−9-10−5M) in the presence or absence of endothelium in the diabetic (DM) vessels, n = 5/group, **p<0.001 vs. Endothelium-intact, Mean ± SD; E, Traces showing the primers of SK-3 and SK-4 specificity; F, Bar graph showing the fold changes in SK-3 and SK-4 mRNA expression of atrial tissue samples collected from diabetic and non-diabetic patients, n = 4/group, mean ± SD; G, Representative immunoblots of human right atrial tissue lysates for SK-3 and SK-4 (IK-1); H, Densitometric analysis of signal intensity (fold changes) in the SK-3 and SK-4 protein expression of atrial tissue samples obtained from diabetic (DM) and non-diabetic patients (ND), n =6/group; I, Immunofluorescence staining of SK-3 and SK-4 (IK-1) in the cultured human coronary arterial endothelial cells (HCAECs) from diabetic (DM) and non-diabetic (ND) patients. J, Densitometric analysis of optical density, mean ± SD, n = 4/group; NS = no significances.