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. 2020 May 18;20(2):838–845. doi: 10.3892/etm.2020.8764

Figure 1.

Figure 1

Met ameliorates obesity and metabolic disorders in HFD-induced obese mice after 24 weeks. (A) Met decreased the body weight, (B) waist circumference and (C) the Lee index in mice from the HFD+Met group compared with those in the HFD group. (D) Between the two HFD groups of mice, hyperglycemia, (E) hyperinsulinaemia and (F) HOMA-IR were significantly improved after Met treatment compared with those in untreated mice. (G) The effect of Met on impaired glucose tolerance, as measured by the oral glucose tolerance test. Right: AUC. Data are expressed as mean ± SEM, n=8 per group. ***P<0.001 vs. control; ΔΔΔP<0.001 vs. HFD. AUC, area under the curve; HFD, high fat diet; HOMA-IR, homeostasis model assessment of insulin resistance; OGTT, oral glucose tolerance test; Met, metformin.