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. 2020 May 18;20(2):838–845. doi: 10.3892/etm.2020.8764

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Copyright: © Du et al.

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited, the use is non-commercial and no modifications or adaptations are made.

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Effect of Met on the expression level of genes and proteins associated with the Nrf2/Keap1 signaling pathway in the cardiac tissue of the three experimental groups. (A) mRNA levels of NFE2L2, (B) KEAP1 and (C) HMOX-1. (D) Representative western blot images of proteins associated with the Nrf2/Keap1 signaling pathway. (E) Densitometry analysis of Nrf2, (F) Keap1 and (G) HO-1 expression. The relative densitometry is expressed as the ratio of Nrf2, Keap1 or HO-1 to GAPDH. Data are presented as mean ± SEM; n=6 per group. ^*^*P<0.01 vs. Control; ^ΔP<0.05 vs. HFD. HFD, high fat diet; HO-1, heme oxygenase 1; Keap1, kelch-like ECH-associated protein 1; HMOX-1, HO-1 gene; Met, metformin; Nrf2, nuclear factor (erythroid-derived 2)-like 2; NFE2L2, Nrf2 gene.