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. Author manuscript; available in PMC: 2021 Mar 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2020 Jan 2;40(3):638–655. doi: 10.1161/ATVBAHA.119.313248

Figure 3.

Figure 3.

Echocardiographic measurements of AoV function of 5 month old mice, 4 months of high fat diet in all models except WT control. (WT: n=11 LDLR−/−: n=17, LDLR−/−IKKBvalveKO: n=11) A,B,C. Mean AoV peak jet velocity (mm/s), Peak gradient (mmHg), and Mean gradient (mmHg) from Pulsed-wave Doppler imaging, calculated using the average peak from > three cardiac cycles for each mouse. D. Ratio of Aortic Root Systolic:Diastolic ratio calculated from M-mode echocardiographic measurements of aortic root diameter during peak diastole and systole. E. Cardiac Ejection Fraction percentage calculated from parasternal long-axis ventricular volume at peak systole and diastole. Asterisks indicate statistically significance, *: p < 0.05, **: p < 0.005, ***: p < 0.0005).