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Knockdown of CacyBP/SIP induces Saos-2 cell apoptosis and cell cycle arrest. (A and B) The percentage of apoptotic cells was determined with Annexin V-APC. (C and D) Flow cytometry was performed to evaluate G1/S arrest in Saos-2 cells following knockdown of CacyBP/SIP. **P<0.01. CacyBP/SIP, calcyclin-binding protein/Siah-1-interacting protein; sh, short hairpin RNA; Ctrl, control; OD, optical density.
