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. 2020 Jul 9;44(3):1049–1063. doi: 10.3892/or.2020.7683

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Copyright: © Pan et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 6. — Effects of shikonin on tumor metastasis and growth in vivo. (A) Representative images of lung tissue and hematoxylin and eosin (H&E)-stained metastatic lung nodules. (B) Quantification of the number of metastatic nodules on lung surface. (C) Tumor volume and (D) weight of the control and shikonin treatment groups. (E) Representative immunohistochemistry images of p-STAT3, E-cadherin, N-cadherin and vimentin expression in the tumor tissues derived from the A549 ×enografts. Data are presented as mean ± SD, *P<0.05, **P<0.01, compared with the control group. p-STAT3, phosphorylated signal transducer and activator of transcription 3.