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. 2020 Jul 17;2020(7):CD005331. doi: 10.1002/14651858.CD005331.pub3

Ataoglu 2003.

Study characteristics
Methods Study design: randomised controlled trial
Study grouping: parallel group
Adequate power (evidence of power calculation): none mentioned
Allocation concealment method: no information
Blinding of outcome assessors: participants were assessed by a psychiatrist who was unaware of the treatment group
Check of blinding: none mentioned
Duration of study: 6 weeks
Randomisation method: computer
Participants Baseline characteristics
Intervention
  • n: 15

  • Duration of symptoms: 34 days

  • Age (mean): 23 (range 16–30) years

  • Sex (% woman): 100%

  • Educational statusno/primary school/high school: PI group consisted of 5 illiterates and 10 primary school graduates.


Control
  • n: 15

  • Duration of symptoms: 48 days

  • Age (mean): 27 (range 18–35) years

  • Sex (% woman): 93%

  • Educational statusno/primary school/high school: diazepam‐treated group consisted of 3 illiterates, 11 primary school graduates, and 1 high school graduate.


Overall
  • n: 30

  • Duration of symptoms: 42 days

  • Sex (% woman): 97%


Inclusion criteria: people admitted to the emergency unit with pseudoseizure. The diagnoses were based on DSM‐IV criteria for conversion disorder.
Exclusion criteria: abnormal EEG, organic disease, axis I or II disorder, previous psychiatric treatment
Pretreatment: no statistically significant differences at baseline between groups
Interventions Intervention characteristics
Intervention
  • Description: PI; 3 weeks as inpatients, with 2 daily session of PI

  • Length of treatment: 3 weeks of inpatient treatment

  • Longest follow‐up after end of treatment: 3 weeks

  • Comedications/other treatments while in the study: none


Control
  • Description: diazepam 5–15 mg with appointments on days 10, 20, 30 and 45 of treatment to review their progress, to reinforce the use of diazepam, and to regulate the dosage.

  • Length of treatment: 45 days

  • Longest follow‐up after end of treatment: none

  • Comedications/other treatments while in the study: none

Outcomes Dropout
  • Outcome type: dichotomous


No conversion symptoms in last 2 weeks
  • Outcome type: dichotomous


Mental stateanxiety (HDRS)
  • Outcome type: continuous

Notes  
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk Quote: "Finally, thirty patients (29 women and 1 man), diagnosed as conversion disorder were randomly divided into two groups by means of a computer."
Allocation concealment (selection bias) Unclear risk No information provided.
Blinding of participants and personnel (performance bias)
All outcomes High risk Quote: "Patients treated with diazepam were offered appointments at the days 10‐20‐30‐45 of treatment to review their progress, to reinforce the use of diazepam, and to regulate the dosage of diazepam."
Quote: "The patients in the PI group were informed about the nature of the treatment, what was expected of them, and approximately how long the treatment would last. The relationship between."
Blinding of outcome assessment (detection bias)
All outcomes Low risk Quote: "All patients were assessed by a psychiatrist who was undisclosed to the subjects' group throughout the study."
Incomplete outcome data (attrition bias)
All outcomes Low risk There were no dropouts.
Selective reporting (reporting bias) Unclear risk No protocol available.
Other bias Low risk No apparent sources of bias.