Table 2.
Different urinary biomarkers in relation to the activity of lupus nephritis.
Biomarkers that correlate with activity in longitudinal studies | Biomarkers that correlate with activity in cross-sectional studies | Biomarkers that correlate with prognosis |
---|---|---|
MCP-1 | Urine Osteoprotegerin | MCP-1 |
NGAL | Urine CXCR3⁺-CD4⁺ T cells | VEGF |
TWEAK | Urine FoxP3 mRNA expression | STAT-1 |
Urine endothelin-1 | IP-10 | |
VCAM-1 | CXCR3 | |
TGF-β | TGF-β |
AbbreviationsMCP-1: monocyte chemoattractant protein-1; NGAL: neutrophil gelatinase-associated lipocallin; TWEAK: TNF-like weak inducer of apoptosis; FOXP3: forkhead box protein P3; VCAM: vascular cell adhesion molecule 1; TGF-β: transforming growth factor beta; VEGF: Vascular Endothelial Growth Factor;; STAT-1: Signal transducer and activator of transcription; IP-10: Interferon gamma-induced protein 10.