Table 2.
Association between family history of autoimmune disease with time to pregnancy, live birth, and pregnancy loss among women in the EAGeR Trial (2006–2012).
| FOR/RR (95% CI) | Any family history of autoimmune disease versus no family history | ||
|---|---|---|---|
| Time-to-Pregnancy | Unadjusted | FOR (95% CI) | 0.92 (0.72, 1.18) |
| Adjusted | FOR (95% CI) | 0.93 (0.73, 1.20) | |
| Live birtha | Unadjusted | RR (95% CI) | 0.83 (0.69, 1.00) |
| Adjusted | RR (95% CI) | 0.84 (0.70, 1.01) | |
| Any pregnancy lossb | Unadjusted | RR (95% CI) | 1.51 (1.11, 2.05)∗ |
| Adjusted | RR (95% CI) | 1.50 (1.10, 2.05)∗ | |
| Clinical lossb | Unadjusted | RR (95% CI) | 1.46 (0.98, 2.17) |
| Adjusted | RR (95% CI) | 1.40 (0.94, 2.10) |
CI, confidence interval; FOR, fecundability odds ratio; RR, risk ratio.
All models were adjusted for age (years), body mass index (BMI, kg/m2), treatment assignment (LDA vs placebo), race, income, and alcohol.
Models for live birth are restricted to n = 1088 women who completed the trial and had complete information on pregnancy outcomes. Of these, n = 152 reported any family history of autoimmune disease.
Models for pregnancy loss are further restricted to women who achieved a hCG pregnancy, with inverse probability weights used control for potential selection bias introduced by restricting to women who achieved pregnancy. Weights were based on factors associated with becoming pregnancy, including age, parity, marital status, number of prior losses and treatment assignment. Weighted log-binomial regression was used to estimate risk ratios and 95% confidence intervals.