Fig. 3.

Immune response of DCs from healthy donors to different yeasts strains. (A) Principal component Analysis of cytokines profiles of yeast strains according to the different species and sources. Boxplots recapitulate the coordinates (horizontal boxplots show PC1, vertical box plots show PC2) of strains grouped according to their species or isolation source. * and # indicate p-values< 0.05, fdr corrected, calculated with Wilcoxon and Levene tests respectively. (B) Strain-specific cytokine profiles of DCs, challenged with S. cerevisiae (light grey) and Candida spp. (black and dark grey) strains. DCs from healthy donors (n ​= ​6) were stimulated with fungal cells for 24 ​h and cultures supernatants used for IL-6, IL-10,IL-1β,TNF-α, IL12p70 and IL-23 measurement. For S. cerevisiae strains, different sources of isolation are indicated: laboratory, natural environment (such as soil, tree), gut, and grape. Gut isolates are indicated as isolated from CD, UC patients or healthy children (HC). Bars indicate the average, error bars indicate the standard error.