Fig. 4.
CCL28 mRNA expression differs between long-term and short-term PSC livers.
A: In situ hybridization (ISH) of CCL28 on FFPE sections, 40x magnification. Representative pictures of short-term PSC-IBD (PSC-IBDST), long-term PSC-IBD (PSC-IBDLT) and control liver. Colon tissue was used as a positive control (lower panel). B: Presence of CCL28 (score 0–3) in biliary epithelium of livers from controls (n = 7), PSC-IBDST (n = 15), PSC-IBDLT (n = 6) and PBC (n = 6) patients. C: Ratio of CCL28/CK7 mRNA expression in livers of control patients (n = 10) and PSC-IBDLT patients (n = 8). D: mRNA expression of CCL25 in ileum tissue (n = 5) and livers of control patients (n = 9) and long-term PSC-IBD patients (n = 8). Statistical testing was performed using the Mann-Whitney U test for comparing 2 groups, Kruskal-Wallis with Dunn’s correction for multiple testing for comparing more than 2 groups. Data presented as median. A p-value <0.05 was considered statistically significant.