Fig. 5.
CXCL12 is highly expressed by biliary epithelial cells, as well as on endothelial cells in PSC liver.
A: Representative picture of immunohistochemistry of CXCL12 on FFPE colon sections, 10x magnification, PSC-IBD colon. B: Staining intensity (0–3) of CXCL12 on colon epithelium of IBD patients (n = 9) and PSC-IBD patients (n = 15). C: Representative picture of immunohistochemistry of CXCL12 on FFPE liver sections, 10x magnification, short-term PSC-IBD (PSC-IBDST) liver. Positive biliary epithelial cells are marked with the filled arrow, positive endothelial cells with the open arrow. D: Staining intensity (0–3) of CXCL12 on liver tissue of controls (n = 5), PSC-IBDST livers (n = 18) and PBC livers (n = 17) (left) and control livers (n = 7) and long-term PSC-IBD (PSC-IBDLT) livers (n = 6) (right). Statistical testing was performed using the Mann-Whitney U test for comparing 2 groups and Kruskal Wallis with Dunn’s correction for multiple testing for comparing more than 2 groups. Data presented as median. A p-value <0.05 was considered statistically significant (∗p < 0.05).