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. 2020 May 15;20(2):1021–1029. doi: 10.3892/etm.2020.8758

Figure 3.

Figure 3

ICAM1 is upregulated in brain endothelial cells and LFA1 is elevated in brain tissue T cells collected from MPTP-treated mice. (A) Representative images of ICAM1 in brain tissue endothelial cells of saline- or MPTP- treated mice. MPTP-treated mice exhibited increased levels of ICAM1. (B) Endothelial cells collected from the brains of MPTP-treated mice expressed significantly higher levels of ICAM1 4 days after MPTP injection (n=9). Experiments were performed in triplicate. ****P<0.0001. (C) Representative images of LFA1 expressed in different tissues of MPTP-treated mice. Brain tissue exhibited higher expressions of LFA1 on T cells. T cells (CD45+CD3+) were collected from the blood, spleen and brain of MPTP-treated mice. (D) T cells in the brain of MPTP-treated mice expressed significantly increased levels of LFA1 compared with the blood and spleen at day 4 after MPTP injection. n=9. Experiments were performed in triplicate. *P<0.05 and ***P<0.001. ICAM1, intercellular adhesion molecule 1; LFA1, lymphocyte function-associated antigen-1; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.