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. 2020 May 15;20(2):1021–1029. doi: 10.3892/etm.2020.8758

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Copyright: © Li et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Blocking of ICAM1 or CD11a attenuates the severity of MPTP-induced PD in mice. (A) Blocking of ICAM1 or CD11a increased the levels of TH⁺ cells at day 4 after MPTP injection. Mouse behaviour assessed by open field tests showed improved clinical presentation in those treated with ICAM1 or CD11a blockade at day 4 after MPTP injection, including (B) distance moved, (C) rears and (D) grooms. n=9. Experiments were performed in triplicate. ^**P<0.01 and ^***P<0.001. ICAM1, intercellular adhesion molecule 1; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; TH, tyrosine hydroxylase; CTRL, control; α-ICAM1, anti-ICAM1 antibodies; α-CD11a, anti-CD11a antibodies.