Table 3.
Associations of MSA/MAA with IIM at different antibody intensity levels.
| Antibody | IIM (n = 187) |
non-IIM (n = 632) |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| Number Neg |
Number Weak posa | Number Posa |
Number Neg | Number Weak posa | Number Posa | OR pb OR wpb | 95% CIc | Pd | |
| Jo-1 | 179 | 1 | 18 | 622 | 5 | 5 | 13.3 | 4.87–36.42 | <0.001 |
| 0.7 | 0.08–6.38 | ||||||||
| EJ | 176 | 0 | 2 | 629 | 1 | 2 | 3.4 | 0.47–24.30 | 0.372 |
| ∞ | ∞ | ||||||||
| OJ | 185 | 1 | 0 | 630 | 1 | 1 | ∞ | ∞ | 0.567 |
| 3.4 | 0.21–54.41 | ||||||||
| PL-7 | 186 | 4 | 4 | 609 | 15 | 8 | 1.7 | 0.50–5.71 | 0.673 |
| 0.9 | 0.29–2.76 | ||||||||
| PL-12 | 179 | 3 | 1 | 623 | 6 | 3 | 1.1 | 0.11–10.97 | 0.748 |
| 1.7 | 0.42–6.87 | ||||||||
| SRP | 181 | 2 | 9 | 617 | 14 | 1 | 31.56 | 3.97–250.73 | <0.001 |
| 0.5 | 0.11–2.24 | ||||||||
| Mi-2α | 174 | 2 | 6 | 630 | 2 | 0 | ∞ | ∞ | <0.001 |
| 3.5 | 0.49–25.16 | ||||||||
| Mi-2β | 177 | 2 | 4 | 620 | 9 | 3 | 4.6 | 1.01–20.59 | 0.089 |
| 0.86 | 0.16–3.55 | ||||||||
| MDA5 | 183 | 2 | 8 | 626 | 5 | 1 | 28.3 | 3.51–227.73 | <0.001 |
| 1.4 | 0.27–7.35 | ||||||||
| NXP2 | 185 | 3 | 1 | 628 | 2 | 2 | 1.7 | 0.15–19.03 | 0.126 |
| 5.1 | 0.85–31.04 | ||||||||
| TIF1-γ | 183 | 5 | 8 | 622 | 5 | 5 | 5.7 | 1.84–17.70 | <0.001 |
| 3.6 | 1.02–12.48 | ||||||||
| SAE1 | 179 | 0 | 2 | 630 | 2 | 0 | ∞ | ∞ | 0.025 |
| ∞ | ∞ | ||||||||
| Ku | 168 | 4 | 4 | 618 | 7 | 7 | 2.0 | 0.57–6.81 | 0.309 |
| 2.0 | 0.57–6.81 | ||||||||
| PM/Scl-75 | 174 | 4 | 9 | 603 | 23 | 6 | 5.2 | 1.82–14.80 | 0.002 |
| 0.6 | 0.20–1.77 | ||||||||
| PM/Scl-100 | 177 | 4 | 6 | 613 | 12 | 7 | 3.0 | 0.98–8.94 | 0.126 |
| 1.2 | 0.36–3.62 | ||||||||
a
Data is not corrected for multiple antibodies in one patient.
b
OR; odds ratio at weak positive level (wp), odds ratio at positive level (p) calculated using logistic regression analysis.
c
95% confidence interval of odds ratio’s.
d
Logistic regression analysis of IIM vs non-IIM with positive, weak positive and negative antibody.