Table 5.
Genotypes absolute frequencies of HLA-DRB1 shared epitope, D70+ and D70- in patients with Autoimmune Thyroid Disease and Rheumatoid Arthritis.
| Group Genotype | RA & AITD N = 45 |
Healthy Individuals N = 234 |
pC | OR | IC95% | |||
|---|---|---|---|---|---|---|---|---|
| N | F | N | f | |||||
| SE/SE | 8 | 0.178 | 6 | 0.026 | 0.00009 | 8.2 | 2.7 | 25.03 |
| SE/D70- | 12 | 0.267 | 17 | 0.073 | 0.0003 | 4.6 | 2.03 | 10.59 |
| SE/D70- | 6 | 0.133 | 6 | 0.026 | 0.004 | 5.8 | 1.79 | 19.05 |
| D70-/D70- | 2 | 0.044 | 5 | 0.021 | 0.699 | 2.1 | 0.4 | 11.34 |
| D70-/D70+ | 11 | 0.244 | 7 | 0.030 | 5E-07 | 10.5 | 3.81 | 28.92 |
| D70+/D70+ | 6 | 0.133 | 16 | 0.068 | 0.239 | 2.1 | 0.77 | 5.69 |
Abbreviations: Autoimmune Thyroid Disease (AITD), confidence interval (CI), frequency (f), odds ratio (OR), corrected probability value (pC), Rheumatoid Arthritis (RA). Alleles with aspartic acid at position 70 (D70+), which confers a protective role to the carrier allele. Alleles with a different amino acid from aspartic acid at position 70 (D70-). For detailed information of alleles included in each group see Table 2 in supplementary materials.