Table 3.
AutoAbs associated with ILD in PM/DM, and additional clinical associations.
| AutoAb | Prevalence (%) | Disease association | Clinical associations | |
|---|---|---|---|---|
| Aminoacyl tRNA synthetases | ||||
| Jo-1 | 15–30 | PM, DM | Anti-synthetase syndrome | |
| PL-7 | <5 | PM, DM | Anti-synthetase syndrome | |
| PL-12 | <5 | PM, DM, CADM | Anti-synthetase syndrome, ILD | |
| EJ | <5 | PM, DM | Anti-synthetase syndrome | |
| OJ | <5 | PM, DM | Anti-synthetase syndrome, ILD | |
| KS | <1 | PM, DM | ILD | |
| MDA5/CADM140 | 15–20 | CADM/ADM | CADM, rapidly progressive ILD, severe skin manifestations | |
Abbreviations: CADM, clinically amyopathic dermatomyositis; DM, dermatomyositis; ILD, interstitial lung disease; PM, polymyositis.