Table 2.
Hepatic cell type realm derived from ontogenetic developments with involvement of complement component.
| Origin | Cell type | Cytokin | Crosstalk complement | resident(r) transient (t) |
Main function | Literature | |
|---|---|---|---|---|---|---|---|
| Producing /responsive |
cytokine | ||||||
| Endoderm | Hepatocyte CXC reponders |
Hepatocyte growth factor | IL-1β, IL-6 IL-8 |
C1r/s,C4,C2,C4bp C3, fB C1 –C9 (excl. C1q,C7) |
r | Protein synthesis | [32] |
| Hepatic sinusoidal cells | Produce IL-6 | ||||||
| Mesoderm | Myeloid | + | r | Innate immune defense | [33] | ||
| Kupffer Stellate Cells (Monocytes/Macrophages) Polymorphonuclear Leukocytes, Adipocytes, Dendritic Cells, NK cells Innate lymphoid cells |
Responsive Producing TNF, IL-2 |
IL-10 | C1q, C7, D, P | r t |
[2,34] [35] |
||
| Mesoderm | Lymphoid iNKT | Helper Cells responsive to IL-2 IL-9 produced by helper cells |
thymus | t | Innate and acquired immune defense | ||