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. 2020 May 18;20(2):968–977. doi: 10.3892/etm.2020.8767

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Copyright: © Ling et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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The role of the ANGPT/TEK pathway in SC and TM. (A) Normally, the aqueous humor is drained via the TM and SC-ECs, along with the formation of giant vacuoles. TEK combines with ANGTP1 primarily, while it has limited compensation from ANGPT2. ANGPT/TEK signaling is important for maintaining the integrity and function of SC and thus ensures that the aqueous humor flows out fluently. (B) Absence of continuous ANGTP/TEK signaling results in an increase of EC apoptosis, as well as a decrease of the formation of giant vacuoles and a reduction of the aqueous humor flow going through SC. The accumulated aqueous humor leads to degeneration of the TM and limitation of SC development. TEK, TEK receptor tyrosine kinase; ANGTP1, angiopoietin 1; TM, trabecular meshwork; SC, Schlemm's canal; ECs, endothelial cells.

The role of the ANGPT/TEK pathway in SC and TM. (A) Normally, the aqueous humor is drained via the TM and SC-ECs, along with the formation of giant vacuoles. TEK combines with ANGTP1 primarily, while it has limited compensation from ANGPT2. ANGPT/TEK signaling is important for maintaining the integrity and function of SC and thus ensures that the aqueous humor flows out fluently. (B) Absence of continuous ANGTP/TEK signaling results in an increase of EC apoptosis, as well as a decrease of the formation of giant vacuoles and a reduction of the aqueous humor flow going through SC. The accumulated aqueous humor leads to degeneration of the TM and limitation of SC development. TEK, TEK receptor tyrosine kinase; ANGTP1, angiopoietin 1; TM, trabecular meshwork; SC, Schlemm's canal; ECs, endothelial cells.