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. 2020 Jul 7;44(3):863–872. doi: 10.3892/or.2020.7674

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Copyright: © Tsuchihashi et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 5. — Effect of alpelisib on cell proliferation and PI3K signaling in HSC-3 OSCC cell line. (A) HSC-3 cells were exposed to various concentrations of alpelisib, (0.1 to 100 µM) and the percentage cell viability and drug concentration that inhibited cell growth by 50% (IC₅₀) were calculated. (B) HSC-3 cell line was exposed to alpelisib at the IC₅₀ concentrations and subsequently assessed for PI3K signaling and phosphorylated protein expression using western blot analysis. *P<0.05, **P<0.01. Ctrl, control.

Figure 5. — Effect of alpelisib on cell proliferation and PI3K signaling in HSC-3 OSCC cell line. (A) HSC-3 cells were exposed to various concentrations of alpelisib, (0.1 to 100 µM) and the percentage cell viability and drug concentration that inhibited cell growth by 50% (IC₅₀) were calculated. (B) HSC-3 cell line was exposed to alpelisib at the IC₅₀ concentrations and subsequently assessed for PI3K signaling and phosphorylated protein expression using western blot analysis. *P<0.05, **P<0.01. Ctrl, control.