Table 3.

In silico predictions of biological activities of validated toxins identified in the venom of A. rondoniae spiders.

	Antimicrobial activity				Antitumoral activity
Peptide	Bacterial	Viral	Fungal		RFACP	Prob.	SVMACP	Prob.
Gomesin	0.985	0.898	0.973		ACP	0.668	ACP	0.926
Rondonin	0.671	0.301	0.903		Non-ACP	0.400	Non-ACP	0.447
P9	0.997	0.940	0.992		Non-ACP	0.479	ACP	0.816
mBD4	0.990	0.773	0.968		Non-ACP	0.371	ACP	0.837
Aurein 1.2	0.940	0.913	0.917		ACP	0.870	ACP	0.935
HNP-1	0.920	0.920	0.950		ACP	0.879	ACP	0.938
PLPVFV	0.623	0.586	0.515		ACP	0.639	ACP	0.656
VVVPFVV	0.645	0.538	0.432		ACP	0.637	ACP	0.635
VENLAEP	0.083	0.046	0.028		Non-ACP	0.296	Non-ACP	0.508
VLPPLKF	0.801	0.794	0.828		ACP	0.632	ACP	0.740
VPPILKY	0.751	0.410	0.429		ACP	0.501	ACP	0.528
YPPPPPPPH	0.542	0.382	0.406		Non-ACP	0.442	ACP	0.618
FETPNNPDGKVTKQE	0.133	0.143	0.082		Non-ACP	0.350	Non-ACP	0.164
U1-TRTX-Agm3a	0.843	0.696	0.579		ACP	0.559	ACP	0.878
U1-TRTX-Ar1a	0.994	0.968	0.976		Non-ACP	0.489	ACP	0.862
U1-TRTX-Ar1b	0.987	0.966	0.972		ACP	0.541	ACP	0.903
U2-TRTX-Ar1a	0.940	0.685	0.920		Non-ACP	0.283	ACP	0.624
U3-TRTX-Ar1a	0.996	0.918	0.982		Non-ACP	0.292	Non-ACP	0.360
U3-TRTX-Ar1b	0.997	0.924	0.986		Non-ACP	0.324	Non-ACP	0.381
U4-TRTX-Ar1a	0.981	0.770	0.954		Non-ACP	0.139	Non-ACP	0.121
U4-TRTX-Ar1b	0.978	0.742	0.937		Non-ACP	0.142	Non-ACP	0.128
U5-TRTX-Ar1a	0.996	0.858	0.989		Non-ACP	0.363	ACP	0.519
U6-TRTX-Ar1a	0.986	0.826	0.947		Non-ACP	0.300	ACP	0.538
U7-TRTX-Ar1a	0.991	0.855	0.926		Non-ACP	0.256	Non-ACP	0.302

Antimicrobial activities were predicted by iAMPpred (Meher et al., 2017). Anticancer activities were predicted by MLACP (Manavalan et al., 2017): RFACP, random forest method; SVAMCP, support vector machine method; ACP, anticancer peptide; Non-ACP, nonanticancer peptide.