Fig. 1.

Differential expression of circRNAs in plasma exosomes from patients with GD and healthy control subjects. a Scatter plots with the mean expression values of samples in each group. Raw junction reads for all samples were normalized by total mapped read numbers and were transformed by log2. Each dot represents a single circRNA. The exhibiting fold change is 2.0 of Line 1 and Line 3, whereas the dots on Line 2 indicate circRNAs with equal expression between GD group and healthy control group. b Volcano plot representation of differentially expressed transcripts and their statistical significance. The fold changes are represented in log2 scale as depicted on the x-axis, whereas the − log10 P-value is depicted on the y-axis. Transcripts with greater statistical significance are higher in the plot. The red circles represent circRNA genes that show differential expression with fold changes > 1.2 and P-values < 0.05 between the GD and normal control exosomes samples