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. 2020 Jul 29;17:226. doi: 10.1186/s12974-020-01894-2

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — IFNAR1 deficiency rescues recognition and spatial memory of HIVgp120tg females. Eleven to 14-month-old mice were behaviorally assessed (genotype: n for males/n for females—WT (WT): 11/11, HIVgp120tg (GP): 9/8, IFNAR1KO (KO): 9/11, and IFNAR1KO × gp120 (KOGP): 13/14). Light and dark transfer test for anxiety-like behavior (a); Locomotor (ambulation, center activity, and rearing (b); novel object recognition (c; left panel: males, right panel females); Barnes maze probe test for spatial learning and memory (d; left panel: males, right panel females). Data is presented in combined box-dot plots with the 25th and 75th percentiles. The middle line of the box shows the median, and the mean is indicated by a “+.” Statistical analysis was performed as described in the methods section. ***P < 0.001, **P < 0.01, *P ≤ 0.05; ANOVAs Tukey’s HSD (a, b) and Fisher’s PLSD post hoc tests (c, d); n = 17–27 (males and females) per group/genotype (total n = 86 animals); n.s., not significant.