Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Jul 29;17:226. doi: 10.1186/s12974-020-01894-2

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 5 — HIVgp120 and IFNAR1 cause sex-dependent, differential expression of genes related to neurotransmission systems in the hippocampus. Clustergram heat map of GABA/glutamate system (a) and dopamine/serotonin system (b) showing gene expression profile of WT, HIVgp120tg, IFNAR1-deficient mice with or without HIVgp120. Red indicated the higher gene expression while green indicates the lower gene expression in the sample set. Hippocampus RNA was analyzed using RT² Profiler PCR Array and the associated Qiagen data analysis software. The heat maps represent significantly changed genes as the averages of three biological replicates. The schematic figure to the right represents pre- and post-synaptic distribution of the differentially expressed genes in neurons of each genotype. Genotypes: WT (WT), HIVgp120tg (GP), IFNAR1KO (KO), and IFNAR1KO × gp120 (KOGP); n = 6 animals (3 males and 3 females) per group/genotype (total n = 24 animals)