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. 2020 Jul 29;17:226. doi: 10.1186/s12974-020-01894-2

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — Functional neural gene networks of neurotransmission affected by HIVgp120 and IFNAR1 deficiency. RNA expression data obtained with the GABA/glutamate and dopamine/serotonin RT² Profiler PCR Array were analyzed using IPA software. Green indicates downregulated while red reflects upregulated genes respectively. The components without color represent genes that were included by IPA without experimentally determined expression levels. IPA identified for each sex a different highest scoring gene direct interaction network in which alterations on expression levels were driven by HIVgp120 in the absence or presence of IFNAR1. The solid lines represent a direct relationship and the arrow indicates the direction of action. *Indicates genes for which differential regulation reached significance in the RT² Profiler PCR Array (*P < 0.05; modified t test). RNA expression data were derived from n = 6 animals (3 males and 3 females) per group/genotype (total n = 24 animals)