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. 2020 Jul 29;17:226. doi: 10.1186/s12974-020-01894-2

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 8 — IFNAR1 deficiency abrogates activity loss of ERK1/2 and upregulation of STAT1 in the hippocampus of HIVgp120tg mice. The expression level of phospho-ERK1 and phospho-STAT1 was assessed by Western blot analysis. Representative Western blot of phospho-ERK1/2, ERK1/2, and β-tubulin in the hippocampus (a). The graph shows the quantification of phospho-ERK and ERK by densitometry using normalization to GAPDH (b). Representative Western blot of phospho-STAT1, STAT1, and β-tubulin in the hippocampus (c). The graph shows the densitometry analysis of phospho-STAT1 and STAT1 normalized to GAPDH (d). Genotypes: WT (WT), HIVgp120tg (GP), IFNAR1KO (KO), and IFNAR1KO × gp120 (KOGP). Values are presented in combined box-dot plots with the 25th and 75th percentiles. The middle line of the box shows the median, and the mean is indicated by a “+”; number on the bar indicates P value, P < 0.05 as cut-off for significance; n.s., not significant; ANOVA and Tukey’s HSD post hoc test; brain tissues were derived from n = 6 of 11–14-month-old animals (3 males and 3 females) per group/genotype (total n = 24 animals)