Table 2.

Genes differentially regulated in males and females in the GABA/glutamate and dopamine/serotonin neurotransmission systems

GABAergic & glutamatergic neurotransmission systems (male)
HIVgp120			IFNAR1KO			IFNAR1KO gp120
Gene	Fold regulation	Pvalue	Gene	Fold regulation	Pvalue	Gene	Fold Regulation	Pvalue
Gabrr1	4.00	0.041	Gabrb1	1.16	0.003	Cdk5r1	−1.21	0.020
P2rx7	1.46	0.002				Gabra5	−1.32	0.040
Slc1a2	−1.17	0.044				Gabrb1	1.13	0.046
Slc1a3	1.21	0.003				Gabrb3	−1.14	0.035
Slc6a1	−1.21	0.023				Gabrr1	13.52	0.006
Slc7a11	2.52	0.000				Gls	−1.15	0.027
B2m	1.90	0.017				Grin1	−1.29	0.027
						Grin2b	−1.35	0.036
						Grin2c	−1.91	0.041
						Grm5	−1.21	0.026
						Mapk1	−1.24	0.026
						Slc1a3	1.15	0.033
						Slc6a1	−1.18	0.045
						Slc6a12	3.50	0.024
						Slc7a11	2.77	0.000
GABAergic & glutamatergic neurotransmission systems (female)
HIVgp120			IFNAR1KO			IFNAR1KO gp120
Gene	Fold regulation	Pvalue	Gene	Fold regulation	Pvalue	Gene	Fold regulation	Pvalue
Cdk5r1	−1.25	0.047	Aldh5a1	−1.30	0.039	Cacna1a	−1.60	0.011
Gabbr2	−1.36	0.031	Gabbr2	−1.74	0.005	Gnai1	−1.26	0.010
Glul	−1.39	0.014	Grik1	1.36	0.040	Grin2c	−1.77	0.029
Gnai1	−1.27	0.046	Grm1	−1.47	0.030	Pla2g6	1.16	0.015
Gnaq	−1.18	0.005	Grm3	1.21	0.015	Slc7a11	1.85	0.044
Gphn	−1.38	0.025	Itpr1	1.16	0.043
Grik4	−1.66	0.048
Grin2c	−1.71	0.030
Grm7	−1.25	0.021
Grm8	−1.36	0.032
Slc6a1	−1.33	0.023
Slc6a12	−2.50	0.039
Slc6a13	−2.11	0.017
Slc7a11	1.84	0.002
B2m	1.73	0.024
Dopaminergic & serotonergic neurotransmission systems (male)
HIVgp120			IFNAR1KO			IFNAR1KO gp120
Gene	Fold regulation	Pvalue	Gene	Fold regulation	Pvalue	Gene	Fold regulation	Pvalue
Adcy5	−1.27	0.018	Htr2c	−1.27	0.0449	Adcy5	−1.42	0.002
Adrbk1	−1.21	0.045	Htr4	−1.17	0.0391	Adrb2	1.39	0.009
Akt1	−1.14	0.014				Adrbk1	−1.14	0.008
Gfap	14.54	0.000				Akt1	−1.30	0.001
Grk6	−1.15	0.036				Cacna1a	−1.63	0.022
Gsk3a	−1.18	0.023				Ephb1	1.77	0.004
Gsk3b	−1.18	0.029				Fos	1.90	0.014
Htr2c	−1.29	0.023				Gfap	13.82	0.000
Htr3a	−1.21	0.027				Grk6	−1.46	0.003
Htr5a	−1.55	0.032				Gsk3a	−1.27	0.006
Snca	−1.25	0.037				Htr1a	−1.65	0.024
Syn2	−1.20	0.047				Htr4	−1.49	0.008
						Mapk1	−1.27	0.046
						Syn2	−1.34	0.018
Dopaminergic & serotonergic neurotransmission systems (female)
HIVgp120			IFNAR1KO			IFNAR1KO gp120
Gene	Fold regulation	Pvalue	Gene	Fold regulation	Pvalue	Gene	Fold regulation	Pvalue
Adcy5	−1.45	0.020	Arrb1	−1.59	0.018	Arrb1	−1.32	0.033
Adrbk2	−1.26	0.010	Drd1	1.56	0.046	Casp3	1.23	0.024
Arrb1	−1.43	0.014	Grk4	1.45	0.046	Cyp2d22	1.34	0.050
Gfap	10.43	0.001	Pik3ca	−1.37	0.045	Gfap	12.41	0.000
Gsk3b	−1.26	0.016	Ppp1r1b	1.51	0.048	Gsk3b	−1.19	0.036
Itpr1	−1.13	0.040				Pla2g5	4.07	0.025
Tph1	−2.24	0.047				Plcb3	1.31	0.033
B2m	1.89	0.012