Table 3.
Ingenuity Pathway Analysis (IPA) predicted upstream regulators in male vs female
| Upstream regulator | Molecule type | Predicted activation state | Activation z-score | P value | |
|---|---|---|---|---|---|
| Males | |||||
| HIVgp120 | None scored | ||||
| IFNAR1KO | None scored | ||||
| IFNAR1KOgp120 | CREBBP | Transcription regulator | Inhibited | − 2.236 | 0.0000532 |
| Females | |||||
| HIVgp120 | HTT | Transcription regulator | Activated | 2.129 | 2.3E−18 |
| CREBBP | Transcription regulator | Inhibited | − 2.0 | 0.0000145 | |
| IFNAR1KO | CREBBP | Transcription regulator | Inhibited | − 2.0 | 0.000054 |
| IFNAR1KOgp120 | CREBBP | Transcription regulator | Inhibited | − 2.0 | 0.0000209 |