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Overall design of the analyses. FULL contains all available markers and operational taxonomic units (OTU), IR contains informatively reduced markers and OTU, and RR contains randomly reduced markers and OTU. Compared to the base line model M0, M1 includes genomic information, M2 includes microbiome information, M3 includes microbiome and genomic information, and M4 includes genomic, microbiome and genome-by-microbiome interaction information
