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. 2020 Jul 13;44(3):1037–1048. doi: 10.3892/or.2020.7686

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Copyright: © Jeddo et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — OTSSP167 reduces tumorigenesis in vivo. (A) Tumor xenografts were significantly smaller in mice orally fed OTSSP167 compared with the control group. (B) Time-dependent reduction in the volume of the tumor xenografts in mice orally fed OTSSP167 daily. (C) Tumor volumes and (D) tumor weights were significantly lower in the mice fed OTSSP167 compared with the vehicle control. (E) Western blots revealing reduced MELK expression in the tumors of mice fed OTSSP167. **P<0.01, ***P<0.001. MELK, maternal embryonic leucine zipper kinase; p.o, per os; q.d. quaque die.