Table I.
Association between MELK expression and clinicopathological data of osteosarcoma patients.
| MELK expression | ||||
|---|---|---|---|---|
| Parameters | N 25 | High n=10 (40%) | Low n=15 (60%) | P-value |
| Age (years) | 0.6968 | |||
| <18 | 14 | 5 | 9 | |
| ≥18 | 11 | 5 | 6 | |
| Sex | 0.2262 | |||
| Male | 13 | 7 | 6 | |
| Female | 12 | 3 | 9 | |
| Location | 0.1500 | |||
| Extremity | 23 | 8 | 15 | |
| Trunk | 2 | 2 | 0 | |
| Histological subtype | 0.8889 | |||
| Osteoblastic | 8 | 2 | 6 | |
| Fibroblastic | 4 | 3 | 1 | |
| Chondroblastic | 7 | 4 | 3 | |
| Othersa | 6 | 1 | 5 | |
| Metastasis | 0.0414b | |||
| Yes | 13 | 8 | 5 | |
| No | 12 | 2 | 10 | |
| Surgery | 0.4139 | |||
| Amputation | 14 | 7 | 7 | |
| Limb salvage | 11 | 3 | 8 | |
| Response to chemotherapy | 0.0154b | |||
| Good | 13 | 2 | 11 | |
| Poor | 12 | 8 | 4 | |
| Enneking stage | 0.472 | |||
| I | 2 | 0 | 2 | |
| II | 20 | 8 | 12 | |
| III | 3 | 2 | 1 | |
P-values were calculated by Fisher's exact test.
a
Others: Telangiectatic, small-cell, parosteal or undifferentiated osteosarcoma.
b
P<0.05. MELK, maternal embryonic leucine zipper kinase.