Table 2.
Association of serotonin-related gene polymorphisms with PD risk in Chinese Han population
| Gene | SNP | Alleles and Genotypes (n, %) |
PD (n = 233) |
Controls (n = 231) |
Model | OR (95% CI) | p-value | p-valuecorr |
|---|---|---|---|---|---|---|---|---|
| SLC6A4 | rs140701 | C | 76 (16.3) | 110 (23.8) | Allelea | 0.624 (0.450–0.864) | 0.004 | 0.028 |
| T | 390 (83.7) | 352 (76.2) | ||||||
| CC | 10 (4.3) | 13 (5.6) | Additiveb | 0.638 (0.463–0.879) | 0.009 | 0.063 | ||
| CT | 56 (24.0) | 84 (36.4) | Dominantb | 0.546 (0.371–0.804) | 0.004 | 0.028 | ||
| TT | 167 (71.7) | 134 (58.0) | Recessiveb | 0.752 (0.323–1.751) | 0.438 | 1 | ||
| rs3813034 | C | 386 (82.8) | 357 (77.3) | Allelea | 0.705 (0.509–0.975) | 0.034 | 0.238 | |
| A | 80 (17.2) | 105 (22.7) | ||||||
| CC | 164 (70.4) | 139 (60.2) | Additiveb | 0.721 (0.526–0.988) | 0.048 | 0.336 | ||
| CA | 58 (24.9) | 79 (34.2) | Dominantb | 0.636 (0.432–0.935) | 0.025 | 0.175 | ||
| AA | 11 (4.7) | 13 (5.6) | Recessiveb | 0.831 (0.364–1.895) | 0.662 | 1 | ||
| 5-HTTLPR | L | 107 (23.0) | 130 (28.1) | Allelea | 0.761 (0.566–1.024) | 0.071 | 0.497 | |
| S | 359 (77.0) | 332 (71.9) | ||||||
| LL | 22 (9.4) | 20 (8.7) | Additiveb | 0.785 (0.594–1.039) | 0.100 | 0.700 | ||
| LS | 63 (27.0) | 90 (39.0) | Dominantb | 0.632 (0.436–0.916) | 0.021 | 0.147 | ||
| SS | 148 (63.5) | 121 (52.3) | Recessiveb | 1.100 (0.583–2.076) | 0.842 | 1 | ||
| STin2 | 10 | 44 (9.4) | 43 (9.3) | Allelea | 1.016 (0.653–1.580) | 0.944 | 1 | |
| 12 | 422 (90.6) | 419 (90.7) | ||||||
| 10/10 | 5 (2.1) | 2 (0.9) | Additiveb | 1.015 (0.663–1.554) | 0.956 | 1 | ||
| 12/10 | 34 (14.6) | 39 (16.9) | Dominantb | 0.932 (0.575–1.508) | 0.711 | 1 | ||
| 12/12 | 194 (83.3) | 190 (82.2) | Recessiveb | 2.511 (0.482–13.080) | 0.393 | 1 | ||
| HTRA1 | rs6295 | G | 359 (77.0) | 358 (77.5) | Allelea | 1.026 (0.755–1.395) | 0.870 | 1 |
| C | 107 (23.0) | 104 (22.5) | ||||||
| GG | 138 (59.2) | 138 (59.7) | Additiveb | 1.026 (0.754–1.398) | 0.554 | 1 | ||
| GC | 83 (35.6) | 82 (35.5) | Dominantb | 1.022 (0.705–1.480) | 0.560 | 1 | ||
| CC | 12 (5.2) | 11 (4.8) | Recessiveb | 1.086 (0.469–2.513) | 0.772 | 1 | ||
| HTR2A | rs6313 | G | 163 (35.0) | 179 (38.7) | Allelea | 0.868 (0.651–1.111) | 0.234 | 1 |
| A | 303 (65.0) | 283 (61.3) | ||||||
| AA | 106 (45.5) | 86 (37.2) | Additiveb | 0.859 (0.663–1.113) | 0.252 | 1 | ||
| GA | 91 (39.1) | 111 (48.1) | Dominantb | 0.711 (0.490–1.030) | 0.061 | 0.427 | ||
| GG | 36 (15.4) | 34 (14.7) | Recessiveb | 1.059 (0.637–1.761) | 0.749 | 1 | ||
| COMT | rs4680 | A | 143 (30.7) | 118 (25.5) | Allelea | 1.291 (0.969–1.720) | 0.081 | 0.567 |
| G | 323 (69.3) | 344 (74.5) | ||||||
| AA | 24 (10.3) | 15 (6.5) | Additiveb | 1.284 (0.65–1.707) | 0.118 | 0.826 | ||
| GA | 95 (40.8) | 88 (38.1) | Dominantb | 1.297 (0.901–1.869) | 0.175 | 1 | ||
| GG | 114 (48.9) | 128 (55.4) | Recessiveb | 1.654 (0.844–3.240) | 0.236 | 1 |
“A” represent wild type and “a” represent mutant type: allele, a vs. A; additive, aa vs. Aa vs. AA; dominant, aa + Aa vs. AA, recessive, aa vs. Aa +AA. a Chi-square test, b Logistic regression analyses by adjustment for age, gender, educational level and resident location. Pcorr: adjusted by boferroni multiple comparison correction