Table 3.
Genotype and allele frequencies of serotonin-related gene polymorphisms between responder and nonresponder
| Gene | SNP | Alleles and Genotypes (n, %) |
Responder (n = 98) |
Nonresponder (n = 135) |
Model | OR (95% CI) | p-value | p-valuecorr |
|---|---|---|---|---|---|---|---|---|
| SLC6A4 | rs140701 | C | 37 (18.9) | 39 (14.4) | Allelea | 0.726 (0.443–1.188) | 0.201 | 1 |
| T | 159 (81.1) | 231 (85.6) | ||||||
| CC | 5 (5.1) | 5 (3.7) | Additiveb | 0.638 (0.470–1.198) | 0.159 | 1 | ||
| CT | 27 (27.6) | 29 (21.5) | Dominantb | 0.694 (0.391–1.232) | 0.160 | 1 | ||
| TT | 66 (67.3) | 101 (74.8) | Recessiveb | 0.715 (0.201–2.542) | 0.446 | 1 | ||
| rs3813034 | C | 155 (79.1) | 231 (85.6) | Allelea | 0.638 (0.394–1.035) | 0.067 | 0.469 | |
| A | 41 (20.9) | 39 (14.4) | ||||||
| CC | 63 (64.3) | 101 (74.8) | Additiveb | 0.669 (0.423–1.060) | 0.113 | 0.791 | ||
| CA | 29 (29.6) | 29 (21.5) | Dominantb | 0.606 (0.344–1.069) | 0.128 | 0.896 | ||
| AA | 6 (6.1) | 5 (3.7) | Recessiveb | 0.590 (0.175–1.991) | 0.332 | 1 | ||
| 5-HTTLPR | L | 76 (38.8) | 31 (11.5) | Allelea | 0.205 (0.128–0.328) | 0.000 | 0.000 | |
| S | 120 (61.2) | 239 (88.5) | ||||||
| LL | 16 (16.3) | 6 (4.4) | Additiveb | 0.249 (0.155–0.401) | 0.000 | 0.000 | ||
| LS | 44 (44.9) | 19 (14.1) | Dominantb | 0.144 (0.079–0.261) | 0.000 | 0.000 | ||
| SS | 38 (38.8) | 110 (81.5) | Recessiveb | 0.238 (0.090–0.634) | 0.004 | 0.029 | ||
| STin2 | 10 | 22 (11.2) | 22 (8.1) | Allelea | 0.702 (0.377–1.307 | 0.262 | 1 | |
| 12 | 174 (88.8) | 248 (91.9) | ||||||
| 10/10 | 3 (3.1) | 2 (1.5) | Additiveb | 0.734 (0.410–1.315) | 0.372 | 1 | ||
| 12/10 | 16 (16.3) | 18 (13.3) | Dominantb | 0.723 (0.363–1.442) | 0.454 | 1 | ||
| 12/12 | 79 (80.6) | 115 (85.2) | Recessiveb | 0.476 (0.078–2.905) | 0.428 | 1 | ||
| HTRA1 | rs6295 | G | 151 (77.0) | 208 (77.0) | Allelea | 1.000 (0.646–1.549) | 0.999 | 1 |
| C | 45 (23.0) | 62 (23.0) | ||||||
| GG | 59 (60.2) | 79 (58.5) | Additiveb | 1.000 (0.645–1.551) | 0.985 | 1 | ||
| GC | 33 (33.7) | 50 (37.0) | Dominantb | 1.072 (0.631–1.822) | 0.903 | 1 | ||
| CC | 6 (6.1) | 6 (4.4) | Recessiveb | 0.713 (0.223–2.281) | 0.826 | 1 | ||
| HTR2A | rs6313 | G | 62 (31.6) | 101 (37.4) | Allelea | 1.292 (0.875–1.906) | 0.197 | 1 |
| A | 134 (68.4) | 169 (62.6) | ||||||
| AA | 48 (49.0) | 58 (43.0) | Additiveb | 1.252 (0.869–1.805) | 0.199 | 1 | ||
| GA | 38 (38.8) | 53 (39.3) | Dominantb | 1.274 (0.756–2.149) | 0.233 | 1 | ||
| GG | 12 (12.2) | 24 (17.8) | Recessiveb | 1.550 (0.733–3.274) | 0.355 | 1 | ||
| COMT | rs4680 | A | 66 (33.7) | 77 (28.5) | Allelea | 0.786 (0.528–1.169) | 0.234 | 1 |
| G | 130 (66.3) | 193 (71.5) | ||||||
| AA | 11 (11.2) | 13 (9.6) | Additiveb | 0.793 (0.537–1.172) | 0.294 | 1 | ||
| GA | 44 (44.9) | 51 (37.8) | Dominantb | 0.705 (0.418–1.189) | 0.174 | 1 | ||
| GG | 43 (43.9) | 71 (52.6) | Recessiveb | 0.843 (0.361–1.969) | 0.954 | 1 |
“A” represent wild type and “a” represent mutant type: allele, a vs. A; additive, aa vs. Aa vs. AA; dominant, aa + Aa vs. AA, recessive, aa vs. Aa +AA. a Chi-square test, b Logistic regression analyses by adjustment for age, gender, educational level and resident location. Pcorr: adjusted by boferroni multiple comparison correction