Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Jul 29;20:703. doi: 10.1186/s12885-020-07164-x

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 2 — The inhibition of the mevalonate pathway induces apoptosis in human IGROV-1 and A2780 ovarian cancer cells. a Anti-tumor effects mediated by atorvastatin (ATO), simvastatin (SIM), rosuvastatin (ROSU) or zoledronic acid (ZOL) were assessed by the Caspase 3/7 Glo® assay after treatment of IGROV-1 and A2780 cells for 48 h. Induction of apoptosis was further confirmed using Western blot based detection of cleaved poly (ADP-ribose) polymerase (cPARP) 48 h after treatment of IGROV-1 cells and 24 h after treatment of A2780 cells, respectively. The equal protein loading is shown by detection of glyceraldehyde-3-phosphate dehydrogenase (GAPDH). The figures show representative blots which were cropped from original images. Full-length blots are presented in Suppl. Fig. 6. Images were detected using GelCapture 7.0.18 software. b Analysis of the expression of the anti-apoptotic genes survivin (SVV) and B-cell lymphoma 2 (BCL-2) by quantitative real-time-PCR 48 h after treatment of IGROV-1 cells with ATO, SIM, ROSU and ZOL. Data are shown as mean ± SEM of at least three individual experiments. (*p < 0.05; **p < 0.01; ***p < 0.001)