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. 2020 Jul 29;20:703. doi: 10.1186/s12885-020-07164-x

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — The anti-tumor effects by simvastatin (SIM), atorvastatin (ATO), rosuvastatin (ROSU) and zoledronic acid (ZOL) in IGROV-1 cells are mediated by inhibited geranylgeranylation. IGROV-1 cells were treated with ATO (10 μM), SIM (10 μM), ROSU (50 μM) or ZOL (50 μM), and supplemented with 10 μM of either farnesyl pyrophosphate (FPP) or geranylgeranyl pyrophosphate (GGPP) for 48 h. a Cell vitality was assessed by CellTiterBlue® assay. b Apoptosis was measured by the Caspase 3/7 Glo® assay. Data are shown as mean ± SEM of at least three individual experiments. (*p < 0.05; **p < 0.01; ***p < 0.001 vs. respective control (C) or vs. respective treatment (−))