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. 2020 Jul 29;20:703. doi: 10.1186/s12885-020-07164-x

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Statins and zoledronic acid (ZOL) suppress gene and protein expression of pro-inflammatory cytokines in IGROV-1 cells. IGROV-1 cells were treated with increasing concentrations of atorvastatin (ATO), simvastatin (SIM), rosuvastatin (ROSU) or ZOL for 24 h. Expression of tumor necrosis factor (TNF)α and interleukin (IL)8 was assessed by quantitative real-time-PCR (a). Expression of IL6 was assessed by quantitative real-time-PCR after 24 h of treatments (b). Supernatants of treated IGROV-1 cells were collected after 48 h of treatments and analyzed for IL-6 protein levels by human IL-6 ELISA (b.) Data are shown as mean ± SEM of at least three individual experiments. (*p < 0.05; **p < 0.01; ***p < 0.001 vs. respective control (0 μM))