Table 3.
.
| Common GO among vWAT sWAT BM | GO vWAT specific | GO sWAT specific | GO BM specific | |
|---|---|---|---|---|
| COMMON AND SPECIFIC GENE ONTOLOGY ENTITIES IN ND SAMPLES | ||||
| GO BIOLOGICAL PROCESS | Arp2/3 complex-mediated actin nucleation | Carbohydrate metabolic process | Response to toxic substance | Carbohydrate metabolic process |
| Actin filament organization | Response to toxic substance | Response to inorganic substance | Cellular lipid metabolic process | |
| Cell motility | Response to inorganic substance | Small molecule metabolic process | Regulation of leukocyte chemotaxis | |
| Collagen fibril organization | Drug metabolic process | Glutathione metabolic process | Regulation of leukocyte migration | |
| Ribosomal large unit assembly | Small molecule metabolic process | Cellular lipid metabolic process | Granulocyte chemotaxis | |
| Translation | Tissue remodeling | Amino acid metabolism | Negative regulation of cell death | |
| Regulation of peptidase activity | Response to hypoxia | Chemokine-mediated signaling pathway | ||
| Response to endoplasmic reticulum stress | Tissue remodeling | |||
| Chaperone-mediated protein folding | Angiogenesis | |||
| Proteasome-mediated ubiquitin dependent protein catabolic process | Endothelial cell proliferation | |||
| Positive regulation of epithelial cell proliferation | ||||
| Response to oxidative stress | Regulation of leukocyte chemotaxis | |||
| Glucose 6-phosphate metabolic process | Regulation of leukocyte migration | |||
| Glycolytic process | Granulocyte chemotaxis | |||
| ATP metabolic process | Bone morphogenesis | |||
| Chondrocyte differentiation | ||||
| Regulation of cellular response to growth factor stimulus | ||||
| Negative regulation of cell death | ||||
| GO PATHWAYS | Cytoskeletal regulation by Rho GTPase | FGF signaling pathway | FGF signaling pathway | Pyruvate metabolism |
| Integrin signaling pathway | EGF receptor signaling pathway | EGF receptor signaling pathway | Plasminogen activating cascade | |
| Glycolysis | ||||
| Pentose phosphate pathway | ||||
| De novo purine biosynthesis | ||||
| Blood coagulation | ||||
| Inflammation mediated by chemokine and cytokine signaling pathway | ||||
| CHANGES IN HFD SAMPLES | ||||
| GO BIOLOGICAL PROCESS | Drug metabolic process ABSENT | Cellular lipid metabolic process ABSENT | Ribosomal large subunit assembly ABSENT | |
| Small molecule metabolic process ABSENT | Endothelial cell proliferation ABSENT | |||
| Response to Interleukin-1 | Translation ABSENT | |||
| Carbohydrate metabolic process ABSENT | ||||
| Cellular lipid metabolic process ABSENT | ||||
| ATP metabolic process ABSENT | ||||
| Bone morphogenesis | ||||
| Chondrocyte differentiation | ||||
| Tissue morphogenesis | ||||
| ERK1 and ERK2 cascade | ||||
| Response to Interleukin-1 | ||||
| GO PATHWAYS | Blood coagulation ABSENT | CCKR signaling map | Pyruvate metabolism ABSENT | |
| FGF signaling pathway ABSENT | Plasminogen activating cascade | De novo purine biosynthesis ABSENT | ||
| EGF receptor signaling pathway ABSENT | Gonadotropin-releasing hormone receptor pathway | |||