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. 2020 Jun 23;44(3):987–1002. doi: 10.3892/or.2020.7658

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Copyright: © Li et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 7. — Downregulation of MCM6 suppresses the migration and invasion of ESCC cells. (A and B) Migration was attenuated after MCM6 was knocked down in EC109 and KYSE30 cell lines, as detected by wound-healing assays. (C) Similarly, cell migratory ability was also detected, and the results revealed that cell migration was inhibited when MCM6 was silenced in EC109 and KYSE30 cell lines, as evaluated by Transwell assay (Matrigel-uncoated). (D) Invasion was inhibited when MCM6 was silenced in EC109 and KYSE30 cell lines, as evaluated by Transwell assay (Matrigel-coated). All experiments were repeated 3 times independently and presented figures were the most representative figures. ***P<0.001 and ****P<0.001. MCM6, minichromosome maintenance 6 complex component; ESCC, esophageal squamous cell carcinoma.