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. 2020 Jul 28;18:286. doi: 10.1186/s12967-020-02454-1

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — CAAS-based clusters significantly associated with immune microenvironment features (CIBERSORT P > 0.05). a Consensus clustering analysis identification of three clusters (samples, n = 165. The white (consensus value = 0, samples never clustered together) and blue (consensus value = 1, samples always clustered together) heatmap colours display sample consensus. b Heatmap of CAASs ordered by clusters showing differential expression of immune cells between patients. c Heatmap of CAASs ordered by clusters displaying the distribution of immune cells in each patient. The asterisk in the upper right corner of the immune cells indicates that the differential expression is significantly different. “*” represents P < 0.05; “**” represents P < 0.01; “***” represents P < 0.001. d A demonstration of the specific expression of differentially expressed immune cells in clusters according to Fig. 4b and c. e Immune score and stromal score between CAAS-based clusters

Fig. 4 — CAAS-based clusters significantly associated with immune microenvironment features (CIBERSORT P > 0.05). a Consensus clustering analysis identification of three clusters (samples, n = 165. The white (consensus value = 0, samples never clustered together) and blue (consensus value = 1, samples always clustered together) heatmap colours display sample consensus. b Heatmap of CAASs ordered by clusters showing differential expression of immune cells between patients. c Heatmap of CAASs ordered by clusters displaying the distribution of immune cells in each patient. The asterisk in the upper right corner of the immune cells indicates that the differential expression is significantly different. “*” represents P < 0.05; “**” represents P < 0.01; “***” represents P < 0.001. d A demonstration of the specific expression of differentially expressed immune cells in clusters according to Fig. 4b and c. e Immune score and stromal score between CAAS-based clusters