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pSer8Aβ deposition in APP/PS1ΔE9 mice at different ages. Detection of npAβ (a, c and e) and pSer8Aβ (b, d and f) in consecutive sections of APP/PS1ΔE9 mice at 6, 17 and 24 months revealed pSer8Aβ-positive parenchymal and vascular immunoreactivity, which was in most cases less abundant than npAβ-immunoreactivity. Scale bar = 200 μm. Sub, subiculum; DG, dentate gyrus; DGm, dentate gyrus molecular layer. Insets show the magnified areas indicated by the boxes. Scale bar = 50 μm
