. 2020 Jul 29;8:118. doi: 10.1186/s40478-020-00959-w

Table 1.

Examination summary of aged control (AC), Alzheimer’s disease (AD) and Down syndrome (DS) brains

Cases	Age (years)	Gender	Brain region examined	82E1 (Aβ1-x)	7H3D6 (npAβ)	1E4E11 (pSerAβ)	PMI (hours)	Brain weight (grams)	Cause of Death	Braak Stage
Aged Control (AC)
AC-1	72	Female	F	–	–	–	NA	1300	Cardiac arrest	NA
			HC	+	+	(+)			Cardiac arrest	NA
AC-2	53	Male	F	–	–	–	9	1500	Cardiac arrest	NA
			HC	+	–	–			Cardiac arrest	NA
AC-3	60	Female	F	+++	–	–	11	1150	Cardiac arrest; Sepsis	NA
			O	+++	–	–			Cardiac arrest; Sepsis	NA
AC-4	64	Male	HC	+++	+	–	9.5	1380	Congestive heart failure	NA
AC-5	70	Male	F	++	+	(+)	17	1500	Mesothelia carcinoma	NA
			HC	+++	+	+			Mesothelia carcinoma	NA
AC-6	60	Female	F	++	–	–	3.5	1380	COPD; AS	NA
			HC	++	–	–			COPD; AS	NA
AC-7	87	Female	F	+++	+	(+)	NA	NA	Choking	NA
			T/HC	–	–	–				NA
AC-8	74	Male	F	++	–	–	NA	1400	Dead on Arrival	NA
Alzheimer’s Disease (AD)
AD-1	82	Female	F	++++	+	++	16	900	Pneumonia	NA
			HC	+++	+	++			Pneumonia	NA
AD-2	79	Female	F	+++	++	+	13	1040	AD; AS	NA
			HC	+++	+	++			AD; AS	NA
AD-3	91	Female	T	++	+	–	3.5	1370	Pneumonia; AD; AS; Lacunar infarct	III -IV
			HC	+++	+	++			Pneumonia; AD; AS; Lacunar infarct	III -IV
AD-4	71	Male	F	+++	+	++	36	NA	AD; AS	NA
			HC	+++	+	++			AD; AS	NA
AD-5	84	Female	F	+++	–	++	NA	1000	AD; AS; Binswanger	NA
			T	++	++	–			AD; AS; Binswanger	NA
AD-6	92	Female	HC	+++	+	++	7	1210	AD; AS; Infarct	NA
AD-7	78	Male	F	+++	+	++	18	1200	AD; AS	V-VI
			HC	++	–	+			AD; AS	V-VI
AD-8	96	Female	F	++	++	++	21	1050	AD; AS; Infarct	NA
			HC	+++	+	++			AD; AS; Infarct	NA
AD-9	78	Male	P	+	++	+	NA	1180	AD; Subdural hematoma	V-VI
			T/HC	+++	+++	+			AD; Subdural hematoma	V-VI
AD-10	88	Female	P	+++	+	+	24	1220	AD; AS
			HC F	++++	++	+++			AD; AS
AD-11	84	Female	F	+++	–	++	16.5	1110	AD; AS; DLBD	NA
			HC	+++	+	++			AD; AS; DLBD	NA
AD-12	88	Female	F	+++	+	+	24	1050	AD; AS; Infarct	V-VI
			HC	++	++	+			AD; AS; Infarct	V-VI
Down syndrome (DS)
DS-1	47	Male	F	++++	+	++	34	910	Glioblastoma; AD	NA
			T/HC	++++	+	++			Glioblastoma; AD	NA
DS-2	55	Male	F	++++	++	++	NA	1040	Pneumonia; AD	NA
			T	++++	++	+++			Pneumonia; AD	NA
DS-3	46	Female	T/HC	+++	++	++	18	870	Pneumonia; AD	NA

The following semi-quantitative scoring criteria were used: –, no staining; (+), 1–10 plaques; +, 11–30 plaques; ++, 31–50 plaques; +++, 51–100 plaques, and ++++, > 100 plaques per cm². F frontal; HC hippocampal; T temporal; O occipital; P parietal; DLBD Diffuse Lewy Body Disease; COPD Chronic Obstructive Pulmonary Disease; AS Arteriolar sclerosis; NA not available