Table 2.
Transgenic AD-like mouse models in which pSer8Aβ and npAβ deposition has been analyzed. APP, Amyloid precursor protein; PS1, Presenilin-1; h-human; m-mouse; Swe, Swedish; Ind, Indiana; Lon, London; PSEN1, Presenilin-1; KI, Knock-in; Tg, Transgenic; Ref, Reference
| Mouse model | Transgene | Ref. | Transgenic promoter |
Age (months) | Amyloid plaques | CAA lesions | ||
|---|---|---|---|---|---|---|---|---|
| npAβ | pSer8Aβ | npAβ | pSer8Aβ | |||||
| APP Transgenics: | ||||||||
| J20 | hAPP770 | 48 | PDGFβ | 4 (n = 4) | + | – | No | No |
| (K670N/M671L; V717F) | 8 (n = 4) | ++ | + | Yes | Yes | |||
| Swe; Ind mutation | 16 (n = 3) | ++++ | +++ | Yes | Yes | |||
| hAPP751 | hAPP751 | 49 | mouse Thy-1 | 14 (n = 2) | ++++ | +++ | Yes | Yes |
| (K670N/M671L; V717I) | ||||||||
| Swe; Lon mutation | ||||||||
| TgSwDI | hAPP770 | 50 | mouse Thy-1 | 3 (n = 4) | + | + | Yes | Yes |
| (K670N/M671L; E693Q; D694N) | 6 (n = 2) | ++ | + | Yes | Yes | |||
| 12 (n = 4) | +++ | ++ | Yes | Yes | ||||
| Swe; Dutch; Iowa mutation | 24 (n = 4) | ++++ | +++ | Yes | Yes | |||
| APP/PS1 Transgenics: | ||||||||
| APP/PS1ΔE9 | m/hAPP695 | 51 | mouse PrnP | 6 (n = 4) | ++ | + | Yes | Yes |
| (K595N/M596L); | 17 (n = 3) | +++ | ++ | Yes | Yes | |||
| hPS1 deletion of exon 9 | 24 (n = 4) | ++++ | +++ | Yes | Yes | |||
| Swe; PSEN1ΔE9 | ||||||||
| PS/APP |
hAPP695 hPS1 (M146L) Swe; PS1M146L |
52 |
Hamster PrnP (APP) PDGFβ (PS1) |
18 (n = 5) | ++++ | +++ | Yes | Yes |
| APP/PS1/Tau Transgenics: | ||||||||
| 3xTg-AD |
hAPP695 (K670N/M671L); hPS1 (M146V); TauP301L Swe;PS1M146V;MAPT4R0N (P301L) |
53 | mouse Thy-1.2 (APP, Tau) PS1 KI | 5 (n = 4) | ++ | + | No | No |
| 14 (n = 3) | +++ | ++ | Yes | Yes | ||||
| 27 (n = 4) | ++++ | +++ | Yes | Yes | ||||
The following semi-quantitative scoring criteria were used: -, no plaque staining, +, 1–5 plaques; ++, 6–10 plaques; +++, 11–100 plaques; ++++, > 100 plaques. Abbreviations: Ref References; Swe Swedish; Ind Indiana; Lon London; PS1 presenelin-1, MAPT, microtubule-associated protein tau; PDGFβ platelet-derived growth factor B-chain; PrnP prion protein; KI, knock-in