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. 2020 Jun 16;44(3):927–938. doi: 10.3892/or.2020.7647

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Copyright: © Zhou et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — ANGPTL4 induces the expression levels of multiple ATP-dependent transporters and Bcl-xL in tumor cells. (A) The inductive effect of CM or adipocyte^shMock or adipocyte^shANGPTL4 on the protein expression level of ABCB1, ABCC1, ABCG2 and Bcl-xL in SKOV3 cells. Left, representative images of western blot analysis. Right, statistical analysis of western blot assay. The data are presented as the mean ± SD. **P<0.01 vs. SKOV3. (B) The inducing effect of CM or adipocyte^shMock or adipocyte^shANGPTL4 on the mRNA expression level of ABCB1, ABCC1, ABCG2 and Bcl-xL in SKOV3 cells. The data are presented as the mean ± SD. **P<0.01 vs. SKOV3. (C and D) The effect of verapamil and A-1155463 on the efficacy of the chemotherapeutics. The data are presented as the mean ± SD. ***P<0.001 vs. CM/carboplatin or adipocyte/carboplatin). ANGPTL4, angiopoietin-like 4; CM, conditioned medium; sh, short hairpin.