Figure 1.

Effects of DOX on H9C2 PPAR-γ expression and cell viability. (A) PPAR-γ protein expression levels in H9C2 cells treated with various concentrations of DOX for 12 or 24 h were determined by western blotting. GAPDH was used as a loading control and for normalization of semi-quantified expression levels. (B) The Cell Counting Kit-8 assay was performed to assess the effects of DOX treatment on H9C2 cell viability. ^**P<0.01 and ^***P<0.001 vs. 0 µM. DOX, doxorubicin; IC₅₀, half maximal inhibitory concentration; PPAR-γ, peroxisome proliferator-activated receptor-γ.