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. 2020 Jun 4;20(2):1725–1733. doi: 10.3892/etm.2020.8836

Figure 1.

Figure 1

Landscape of MUC16 mutations in CC. (A) An OncoPlot of the top 10 mutated genes in CC samples from TCGA database. The upper bar plot indicates the number of genetic mutations/patient, while the bar plot on the right indicates the number of genetic mutations/gene. The CC pathology types and mutation types are represented as annotations at the bottom. (B) A lollipop plot of MUC16 mutations in CC samples from TCGA database. Amino acid axis labelled for domain. (C) Proportions of MUC16 mutations between endocervical adenocarcinoma and cervical squamous cell carcinoma. (D) Proportions of different types of single nucleotide variants of MUC16 in CC samples from TCGA database. (E) Numbers of different types of single nucleotide variants of MUC16 in CC samples from TCGA database. CC, cervical cancer; TCGA, The Cancer Genome Atlas; TTN, Titin; PIK3CA, phosphatidylinositol 3; MUC4, mucoprotein 4; KMT2C, histone lysine methyltransferase 2C; MUC16, mucoprotein 16; KMT2D, histone lysine methyltransferase 2D; FLG, filaggrin; DMD, duchenne muscular dystrophy; EP300, E1A binding protein p300; SYNE1, spectrin repeat-containing nuclear envelope protein 1.