Figure 4.

MUC16 mutations were involved in immune responses. (A) Volcano plot depicting the NES and negative logarithmically transformed P-value of immune response-associated gene sets in MUC16-mutant and MUC16-wild-type CC samples from TCGA database. Enrichment of (B) B cell-associated and (C) T cell-associated gene sets with overexpression of MUC16, in MUC16-wild-type and MUC16-mutant CC samples from TCGA database. (D) Bar plots depicting the activity level of multiple immune responses in different disease stages between MUC16-mutant and MUC16-wild-type samples of CC from TCGA database. Data are presented as the mean ± standard error of the mean. NES, normalized enrichment score; CC, cervical cancer; TCGA, The Cancer Genome Atlas.