Table II.
Pathway analysis of the differentially methylated regions and their associated genes in the thoracic aortic dissection vs. control group based on Kyoto Encyclopedia of Genes and Genomes pathway analysis.
| Pathway_id | Pathway_name | Pathway_class | Genes_in_list |
|---|---|---|---|
| hsa05200 | Pathways in cancer | Cancers: Overview | MMP2, WNT1, WNT2B, IGF1R, PDGFB, BCL2, PGF |
| hsa04151 | PI3K-Akt signaling pathway | Signal transduction | FGFR2, IFNAR1, PPP2R2C, IGF1R, MDM2, TNXB, RPTOR |
| hsa04010 | MAPK signaling pathway | Signal transduction | FGFR2, DUSP10, ECSIT, RASGRF1, GRB2, PDGFB, MAPT, NFATC2 |
| hsa05205 | Proteoglycans in cancer | Cancers: Overview | MMP2, WNT1, WNT2B, IGF1R, MDM2, ITPR3, GRB2, FGF12 |
| hsa04390 | Hippo signaling pathway | Signal transduction | WNT1, WNT2B, GLI2, WNT3A, APC, TCF7L1, PPP2R2B, WNT3, MPP5 |
| hsa05169 | Epstein-Barr virus infection | Infectious diseases: Viral | PSMD2, MDM2, PSMD7, MAP2K6, BCL2, HDAC4, FCER2, CCNA1 |
| hsa05161 | Hepatitis B | Infectious diseases: Viral | IFNAR1, TICAM1, NFATC3, GRB2, NFATC2, BCL2,TLR3 |
| hsa04310 | Wnt signaling pathway | Signal transduction | WNT1, WNT2B, CTBP2, NFATC3, FBXW11, NFATC2, SFRP2, RAC1 |
| hsa04142 | Lysosome | Transport and catabolism | MFSD8, AP3D1, LAMP1, GBA, NAGPA, CTSA, ARSG, PPT1, CTNS |
| hsa04110 | Cell cycle | Cell growth and death | MDM2, TFDP2, MAD1L1, MCM5, CCNA1, E2F2, TGFB1, TFDP1, MCM7 |
| hsa04916 | Melanogenesis | Endocrine system | WNT1, WNT2B, ADCY7, ADCY9, PRKCA, PRKCG, WNT5B, WNT5A |
| hsa05217 | Basal cell carcinoma | Cancers: Specific types | WNT1, WNT2B, GLI2, SUFU, APC2, WNT5B, WNT5A, FZD3, WNT3A |
| hsa04512 | ECM-receptor interaction | Signaling molecules and interaction | TNXB, COL4A1, ITGB5, LAMA3, COL4A2, ITGB1, CD44, COL1A |
| hsa04340 | Hedgehog signaling pathway | Signal transduction | WNT1, WNT2B, GLI2, SUFU, FBXW11, WNT5B, WNT5A, WNT3A |
| hsa04150 | mTOR signaling pathway | Signal transduction | RPTOR, PRKCA, PRKCG, RPS6KA2, IKBKB, AKT1S1, MTOR, TSC2 |
| hsa05210 | Colorectal cancer | Cancers: Specific types | MLH1, BCL2, RAC1, APC2, TGFB1, BIRC5, APC, TCF7L1, AKT1 |
| hsa05214 | Glioma | Cancers: Specific types | IGF1R, MDM2, GRB2, PDGFB, PRKCA, PRKCG, E2F2, MTOR, AKT1 |
| hsa04710 | Circadian rhythm | Environmental adaptation | PRKAG2, FBXW11, NR1D1, BHLHE41, RORA, RORB, PRKAA1, SKP1 |
hsa, Homo sapiens; ECM, extracellular matrix; MAPK, mitogen-activated protein kinase.