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Schematic design of targeting nonactivatable optical probe (A) and process of utilizing targeted activatable FRET probe (B). Step 1: Internalization of protease activatable molecular probe via a membrane receptor. Step 2: Transmission of excitation energy from donor to acceptor dye quenches the fluorescence of donor. Steps 3 and 4: Recovering fluorescence after releasing quencher moiety when probe binds to active site of diagnostic enzymes.
